Rhode Island Multistate Pharmacy Jurisprudence (MPJE) Practice Exam

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What is the maximum number of days that multidose vials with antimicrobial preservatives can be used after puncture?

14 days
28 days
30 days
60 days

The correct answer is: 28 days

The maximum number of days that multidose vials with antimicrobial preservatives may be used after they have been punctured is 28 days. This guideline is based on stability studies and pharmacopoeial standards that ensure the safety and efficacy of the medication while minimizing the risk of contamination. The presence of antimicrobial preservatives allows for a longer shelf life once the vial has been opened compared to those without preservatives, but there is still a limit to how long they can be safely used. Using the vial beyond 28 days could increase the risk of microbial growth, potentially compromising the integrity of the medication. Other choices reflect timeframes that exceed the recommended usage period for multidose vials with antimicrobial preservatives. It is essential for pharmacists to adhere to these guidelines to maintain patient safety and effective treatment outcomes.