Rhode Island Multistate Pharmacy Jurisprudence (MPJE) Practice Exam

What is the schedule classification for codeine when used in its specified concentrations?

1. C I

2. C II

3. C III

4. C IV

The correct answer is: C II

Codeine is classified based on its concentration and formulation. When codeine is present in higher concentrations, such as those typically found in prescription medications for pain relief, it falls into the category of a Schedule II controlled substance. This classification is due to its potential for abuse, which can lead to severe physical or psychological dependence, justifying the stricter regulatory controls. Schedule II substances require a written prescription and can't be refilled without a new prescription, reflecting their higher risk. Lower concentrations of codeine may fall into different schedules, such as Schedule III if combined with other non-narcotic ingredients and at lower doses. However, in its pure and higher concentration forms, codeine is recognized as a Schedule II substance, necessitating careful monitoring by healthcare providers and regulatory agencies to prevent misuse.