Rhode Island Multistate Pharmacy Jurisprudence (MPJE) Practice Exam

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Which of the following medications is considered to have a narrow therapeutic window?

Ibuprofen
Warfarin
Amoxicillin
Furosemide

The correct answer is: Warfarin

Warfarin is recognized for having a narrow therapeutic window, which refers to the small range between its minimum effective dose and its minimum toxic dose. This characteristic is significant because it means that the margin for error when dosing warfarin is quite small, making careful monitoring essential. The narrow therapeutic window necessitates frequent blood tests (specifically, INR tests) to ensure that the levels of the medication remain within a therapeutic range, thereby preventing complications such as bleeding or thrombosis. This careful balance is critical for patient safety and the effective management of conditions such as atrial fibrillation and the prevention of venous thromboembolism. In contrast, medications like ibuprofen, amoxicillin, and furosemide do not typically require the same level of monitoring and do not present as pronounced a risk for toxicity at standard therapeutic dosages. While these medications can have side effects or interactions, they generally do not have the same narrow therapeutic range as warfarin, which requires a more precise approach to dosing and management.